{"id":873,"date":"2016-05-06T08:41:56","date_gmt":"2016-05-06T08:41:56","guid":{"rendered":"http:\/\/www.virologyhighlights.com\/?p=873"},"modified":"2018-05-25T08:31:48","modified_gmt":"2018-05-25T08:31:48","slug":"does-ifn-s-play-a-key-role-in-the-efficient-growth-of-zika-virus-in-human-epithelial-cells","status":"publish","type":"post","link":"https:\/\/www.elsevierblogs.com\/virology\/does-ifn-s-play-a-key-role-in-the-efficient-growth-of-zika-virus-in-human-epithelial-cells\/","title":{"rendered":"Does IFN-\u00df play a key role in the efficient growth of ZIKA virus in human epithelial cells?"},"content":{"rendered":"

Read the full article on ScienceDirect.<\/a><\/h3>\n

The interplay between ZIKV and IFN-\u00df<\/h2>\n

Text by Philippe Despr\u00e8s and Wildriss Viranaicken<\/em><\/h4>\n

 <\/p>\n

Mosquito-borne Zika virus (ZIKV) has recently gained a medical importance following
\nthe large-scale epidemics in the South Pacific and Latin America. To better
\nunderstand the pathogeny of severe ZIKV-related diseases, e.g. congenital
\nmicrocephaly and Guillain Barr\u00e9 Syndrome, the study of the cell host response to
\nZIKV infection is an absolute prerequisite. Today, there is still a lack of knowledge
\nconcerning the interactions between human cells and ZIKV. The research
\nlaboratories PIMIT and DeTROI in La Reunion island (France) with MIVEGEC in
\nMontpellier (France) have decided to pursue their efforts on the characterization of
\nSouth Pacific epidemic strain of ZIKV in studying the ZIKV permissiveness of human
\nepithelial cells. Our data demonstrated that epidemic strain of ZIKV isolated in
\nFrench Polynesia in 2013 replicates efficiently in A549 cells leading to mitochondrial
\napoptosis. Our work points to a role for IFN-\u03b2 in the efficiency of ZIKV replication in
\nhuman epithelial cells.<\/h4>\n

 <\/p>\n

During the course of the our study, we had been firstly surprised to detect an early
\nproduction of soluble IFN-\u00df in response to ZIKV while viral growth was greatly
\nefficient in A549 cells. It is possible that the soluble IFN-\u03b2 acts in a paracrine manner
\nto protect neighboring cells from viral infection. The second intriguing observation
\nwas that antiviral effect of IFN-\u00df against ZIKV was markedly diminished once viral
\nreplication has been established in these cells. It is likely that ZIKV evades the type-I
\nIFN signaling pathway generated by A549 cells as it has been observed with other
\nflaviviruses such as West Nile and dengue viruses. Another implication of our work is
\na possible role for IFN-\u00df in late induction of apoptosis in A549 cells infected by ZIKV.
\nWhile we have not been able to demonstrate a direct causal relationship between the
\nearly release of IFN-\u00df and the late apoptosis, we postulate that epidemic ZIKV
\nstrains developed a circumvent strategy in which released IFN-\u00df could act in a
\nautocrine manner to delay activation of apoptotic pathway before the virus progeny
\nproduction reaching a plateau.<\/h4>\n

 <\/p>\n

\"AuthorsArrows\"<\/a><\/p>\n

Figure Legend
\n<\/strong><\/h3>\n

Immunostaining of A549 cells infected by ZIKV and ZIKV-infected cells in apoptotic state (Bax +). Arrows: viral antigen (green); Bax (red); nucleus (blue).<\/p>\n

Introducing the authors<\/strong><\/h3>\n

\"Authors\"<\/a><\/p>\n

Pictured from left to right: Philippe Despr\u00e8s, Brice Navitel (DeTroi), Wildriss Viranaicken, Etienne Frumence, Pascale Krejbich-Trotot, Marjolaine Roche, Philippe Rondeau, (DeTroi), Chaker El-Kalamouni, Gilles Gadea<\/h4>\n

About the research<\/strong><\/h3>\n

The South Pacific epidemic strain of Zika virus replicates efficiently in human epithelial A549 cells leading to IFN-\u03b2 production and apoptosis induction<\/a><\/h3>\n

Etienne Frumence, Marjolaine Roche, Pascale Krejbich-Trotot, Chaker El-Kalamouni, Brice Nativel, Philippe Rondeau, Doroth\u00e9e Miss\u00e9, Gilles Gadea, Wildriss Viranaicken, Philippe Despr\u00e8s<\/h4>\n

Virology<\/em>, Volume 493, June 2016, Pages 217\u2013226<\/p>\n","protected":false},"excerpt":{"rendered":"

Read the full article on ScienceDirect. The interplay between ZIKV and IFN-\u00df Text by Philippe Despr\u00e8s and Wildriss Viranaicken   Mosquito-borne Zika virus (ZIKV) has recently gained a medical importance following the large-scale epidemics in the South Pacific and Latin America. To better understand the pathogeny of severe ZIKV-related diseases, e.g. congenital microcephaly and Guillain Read More…<\/a><\/p>\n","protected":false},"author":1,"featured_media":879,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,632,631,630],"tags":[679,684,683,678,686,680,676,687,673,681,682,689,685,677,675,688,674,672],"class_list":["post-873","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlighted-article","category-immunity-to-viruses","category-viral-pathogenesis","category-virus-host-biology","tag-a549-cells","tag-brice-nativel","tag-chaker-el-kalamouni","tag-detroi","tag-dorothee-misse","tag-etienne-frumence","tag-flaviviruses","tag-gilles-gadea","tag-ifn-s","tag-marjolaine-roche","tag-pascale-krejbich-trotot","tag-philippe-despres","tag-philippe-rondeau","tag-pimit","tag-virus","tag-wildriss-viranaicken","tag-zika","tag-zikv"],"_links":{"self":[{"href":"https:\/\/www.elsevierblogs.com\/virology\/wp-json\/wp\/v2\/posts\/873","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.elsevierblogs.com\/virology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.elsevierblogs.com\/virology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.elsevierblogs.com\/virology\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.elsevierblogs.com\/virology\/wp-json\/wp\/v2\/comments?post=873"}],"version-history":[{"count":7,"href":"https:\/\/www.elsevierblogs.com\/virology\/wp-json\/wp\/v2\/posts\/873\/revisions"}],"predecessor-version":[{"id":996,"href":"https:\/\/www.elsevierblogs.com\/virology\/wp-json\/wp\/v2\/posts\/873\/revisions\/996"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.elsevierblogs.com\/virology\/wp-json\/wp\/v2\/media\/879"}],"wp:attachment":[{"href":"https:\/\/www.elsevierblogs.com\/virology\/wp-json\/wp\/v2\/media?parent=873"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.elsevierblogs.com\/virology\/wp-json\/wp\/v2\/categories?post=873"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.elsevierblogs.com\/virology\/wp-json\/wp\/v2\/tags?post=873"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}